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Japanese Journal of Clinical Oncology Advance Access published online on August 11, 2008
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyn073
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© The Author (2008). Published by Oxford University Press. All rights reserved

Chemoradiotherapy Laryngeal Preservation for Advanced Hypopharyngeal Cancer {dagger}

Shyh-Kuan Tai1,2,4, Muh-Hwa Yang2,5, Ling-Wei Wang3,6, Tung-Lung Tsai1,2, Pen-Yuan Chu1, Yi-Feng Wang1, Jui-Lin Huang1 and Shyue-Yih Chang1,4

1 Department of Otolaryngology, Taipei Veterans General Hospital
2 Institute of Clinical Medicine, National Yang-Ming University
3 The Cancer Center, Taipei Veterans General Hospital
4 Department of Otolaryngology, National Yang-Ming University
5 Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital
6 School of Medicine, National Yang-Ming University, Taipei, Taiwan

For reprints and all correspondence: Shyue-Yih Chang, Department of Otolaryngology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan. E-mail: sychang{at}vghtpe.gov.tw

Received May 21, 2008; accepted July 12, 2008

Objective: Laryngeal preservation is a challenge for the treatment of advanced hypopharyngeal cancer. The objective of this study is to evaluate the results of chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer at a single institute and the impact of treatment factors on prognosis.

Methods: The study population consisted of 42 consecutive patients with resectable stage III–IV hypopharyngeal cancer. Patients with T4b tumor, synchronous primary cancer or those treated palliatively were excluded. Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) was performed in 32 (76.2%) patients, whereas primary CCRT was done in the other 10 (23.8%). Patients were grouped according to the dose intensity of chemotherapy and total dose of radiotherapy (RT).

Results: Grade 3–4 toxicities occurred mostly during CCRT. Thirty-five (83.3%) patients received an optimum dose of cisplatin (CT-optimum), 27 (64.3%) received an optimum dose of RT-optimum and 26 (61.9%) received optimum doses of both (CRT-optimum). CT- and RT-optimum both correlated significantly with better disease-free survival (DFS) (P < 0.001 and = 0.003), overall survival (OS) (P < 0.001 and = 0.004) and laryngeal preservation survival (LPS) (P = 0.01 and 0.04). The 3-year DFS, OS and LPS for CRT-optimum patients were 48.1, 50.0 and 45.6%, respectively.

Conclusions: Achievement of optimum treatment dose remains challenging in chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer. Intensive patient care and monitoring by experienced multi-disciplinary teamwork are mandatory. The criteria for selecting patients who will respond to and complete the treatment remain key issues for future investigation.

Key Words: hypopharyngeal cancer • laryngeal preservation • chemotherapy • radiotherapy

{dagger} Presented at the 8th Taiwan–Japan Conference in Otolaryngology Head and Neck Surgery, Taipei, Taiwan, December 16–18, 2005.


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