Japanese Journal of Clinical Oncology Advance Access published online on November 8, 2008
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyn122
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© The Author (2008). Published by Oxford University Press. All rights reserved
Primary Adenocarcinoma of the Small Intestine: Presentation, Prognostic Factors and Clinical Outcome
1 Division of Medical Oncology, Department of Internal Medicine
2 Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea
For reprints and all correspondence: Sang Young Rho, Division of Medical Oncology, Department of Internal Medicine, Uijeongbu St Mary Hospital, College of medicine, Catholic University of Korea, 65-1 Kumoh-dong, Uijeongbu Kyonggi-do 480-130, Seoul, Korea. E-mail: ssuki76{at}catholic.ac.kr
Received June 10, 2008; accepted October 2, 2008
Background: Malignant small intestine tumor accounts for 0.1–0.3% of all malignancies. Although primary adenocarcinoma is the most common histologic subtype, there is no report of the clinical characteristics and natural history in the Asian population.
Methods: We conducted retrospective analysis for the patients with the small intestine adenocarcinoma to explore the clinical characteristics and prognosis. All patients with adenocarcinoma of small intestine diagnosed between March 1997 and March 2007 in the Catholic Medical Center in Korea were identified through the cancer registry. The medical records were reviewed for patient characteristics, treatment and outcome data.
Results: Data on 53 patients were available. Twenty-six patients (49.0%) underwent curative resection and 13 patients receiving adjuvant chemotherapy. Fifteen patients received palliative chemotherapy. Median of overall survival of all patients was 12 months (95% confidence interval (CI): 8.5–15.1 months). Three-year survival and relapse-free survival rates after curative resection was 66.1 and 50.8%, respectively. Median survival of patients received palliative chemotherapy was 8.0 months (95% CI: 3.5–12.4).
Conclusions: The prognosis of primary adenocarcinoma of small intestine was poor, especially in cases where curative resection could not to be performed. Further study on the methods for early detection and effective systemic chemotherapy should be investigated.
Key Words: adenocarcinoma • small intestine • early detection • survival