Skip Navigation



Japanese Journal of Clinical Oncology Advance Access published online on June 23, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp069
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
39/10/638    most recent
hyp069v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Kato, H.
Right arrow Articles by Ishikura, S.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kato, H.
Right arrow Articles by Ishikura, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2009). Published by Oxford University Press. All rights reserved

A Phase II Trial of Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma: Japan Clinical Oncology Group Study (JCOG9708)

Hoichi Kato1, Akihiro Sato2, Haruhiko Fukuda1, Yoshikazu Kagami1, Harushi Udagawa3, Akihiko Togo4, Nobutoshi Ando5, Otsuo Tanaka6, Masayuki Shinoda7, Hideaki Yamana8 and Satoshi Ishikura1

1 National Cancer Center, Tokyo
2 National Cancer Center East, Chiba
3 Toranomon General Hospital
4 Togo Clinic
5 Tokyo Dental College, Tokyo
6 Niigata Cancer Center, Niigata
7 Aichi Cancer Center, Aichi
8 Kurume University Hospital, Fukuoka, Japan

For reprints and all correspondence: Akihiro Sato, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. E-mail: asato{at}east.ncc.go.jp

Received February 5, 2009; accepted May 26, 2009

Objective: The study objective was to evaluate the efficacy and toxicity of chemoradiotherapy with 5-fluorouracil (5-FU) plus cisplatin in patients with Stage I esophageal squamous cell carcinoma (ESCC). The primary endpoint was proportion of complete response (%CR).

Methods: Patients with Stage I (T1N0M0) ESCC, aged 20–75 years, without indication of endoscopic mucosal resection were eligible. Treatment consisted of cisplatin 70 mg/m2 (day 1) and 5-FU 700 mg/m2/day (days 1–4) combined with 30 Gy radiotherapy (2 Gy/day, 5 days/week, days 1–21). The cycle was repeated twice with 1-week split. Salvage surgery was recommended for residual tumor or local recurrence.

Results: From December 1997 to June 2000, 72 patients were enrolled. No ineligible patient or major protocol violation was observed. There were 63 CRs for %CR of 87.5% [95% confidence interval (CI): 77.6–94.1]. Six patients with residual tumor successfully underwent esophagectomy. There was no Grade 4 toxicity. Four-year survival proportion was 80.5% (95% CI: 71.3–89.7), and 4-year major relapse-free survival proportion was 68% (95% CI: 57.3–78.8) (mucosal recurrence removed by endoscopy was not counted as an event).

Conclusions: High CR proportion and survival proportion with mild toxicity suggest that this regimen could be considered as a candidate of new standard treatment to be compared with surgery in patients with Stage I ESCC.

Key Words: esophageal neoplasms • combined modality therapy • clinical trial • Phase II • radiotherapy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.