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Japanese Journal of Clinical Oncology Advance Access published online on June 25, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp070
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© The Author (2009). Published by Oxford University Press. All rights reserved

Allergic Reactions to Oxaliplatin in a Single Institute in Japan

Yasushi Ichikawa1, Ayumu Goto1, Satoru Hirokawa1, Miyuki Kijima1, Takashi Ishikawa2, Takashi Chishima2, Hirokazu Suwa2, Harumi Yamamoto2, Shigeru Yamagishi2, Shunichi Osada2, Mitsuyoshi Ota2 and Shoichi Fujii2

1 Department of Clinical Oncology, Yokohama City University Graduate School of Medicine
2 Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

For reprints and all correspondence: Yasushi Ichikawa, Department of Clinical Oncology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. E-mail: yasu0514{at}med.yokohama-cu.ac.jp

Received February 26, 2009; accepted May 24, 2009

Allergic reactions to oxaliplatin can be severe and are an important cause of discontinuation of treatment. A retrospective review was performed for 105 patients who received FOLFOX regimens between May 2005 and June 2007. Twenty-five cases (23.8%) of allergic reactions were identified, including 9 late onset reactions (8.6%) and 16 immediate reactions (15.2%). Severe allergy (Grades 3 and 4) occurred in seven patients (6.7%). Re-introduction of FOLFOX was attempted for seven immediate onset patients with a severity grade of 1 or 2, and three of these patients (42.9%) showed relapse of allergy. In ~10% of the patients, FOLFOX had to be discontinued due to allergy before the disease became refractory to the regimen. Our experience indicates that allergy to oxaliplatin may be a significant concern and that methods are required for suppression of this allergy.

Key Words: oxaliplatin • FOLFOX • allergy • hypoxemia


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