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Japanese Journal of Clinical Oncology Advance Access published online on August 19, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp096
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© The Author (2009). Published by Oxford University Press. All rights reserved

Estrogen Replacement in Female Lung Cancer During Gefitinib Therapy

Ping-huai Wang1, Hao-chien Wang2 and Chien-chen Tsai3

1 Department of Internal Medicine, Far Eastern Memorial Hospital
2 Department of Internal Medicine, National Taiwan University Hospital
3 Department of Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan

For reprints and all correspondence: Hao-chien Wang, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan. E-mail: haochienwang{at}gmail.com

Received May 12, 2009; accepted July 8, 2009

Estrogen receptor (ER) has been detected in some specimens of lung cancer. Estrogen has an effect on the growth of lung cancer cell lines. An inverse relationship between ER and epithelial growth factor receptor (EGFR) was reported in pre-clinical data. A 70-year-old female with lung adenocarcinoma, who achieved a partial response by gefitinib, underwent estrogen replacement for menopause-associated symptoms during gefinitib therapy. Lung nodules enlarged with 1-month estrogen use and regressed 6 weeks after the end of estrogen therapy. To our knowledge, this is the first case report regarding the interaction between estrogen and EGFR inhibitors.

Key Words: lung cancer • epidermal growth factor receptor • estrogen receptor • hormone replacement • gefitinib


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