Japanese Journal of Clinical Oncology Advance Access published online on October 7, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp105
© The Author (2009). Published by Oxford University Press. All rights reserved
Quality Assurance in the Prospective Multi-institutional Trial on Definitive Radiotherapy Using High-dose-rate Intracavitary Brachytherapy for Uterine Cervical Cancer: The Individual Case Review
1 Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa
2 Department of Radiation Oncology, Cancer Institute Hospital, Tokyo
3 Gunma University Heavy Ion Medical Center, Maebashi
4 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba
5 Department of Radiology, School of Medicine, Kitasato University, Kanagawa
6 Department of Radiation Oncology, Aichi Cancer Center, Nagoya
7 Department of Radiology, Saitama Cancer Center, Saitama
8 Department of Radiology, National Shikoku Cancer Center, Ehime
9 Department of Radiation Oncology, St Luke's International Hospital, Tokyo
10 Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima
11 Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Osaka
12 Radiation Oncology Division, National Cancer Center Hospital, Tokyo, Japan
For reprints and all correspondence: Takafumi Toita, Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan. E-mail: b983255{at}med.u-ryukyu.ac.jp
Received July 14, 2009; accepted July 28, 2009
Objective: To assess compliance with the radiotherapy protocol of a multi-institutional prospective study (JAROG0401/JROSG04-2), which investigated the efficacy and toxicity of definitive radiotherapy using high-dose-rate intracavitary brachytherapy (HDR-ICBT) for early-stage uterine cervical cancer patients.
Methods: Individual case reviews (ICRs) were performed on all 60 study participants. Radiotherapy data were submitted to the quality assurance (QA) committee, which performed ICRs on 16 QA items according to previously selected criteria. The items focused on quality of external beam radiotherapy (EBRT), HDR-ICBT and both. Each item was determined to be either acceptable or a deviation. The QA committee performed ICR three times as planned, two during the patient accrual and the final one just after the final patient accrued. The QA results of the first and second reviews were reported back to the investigators after each ICR.
Results: In 40 cases (67%), all 16 QA items were classified as acceptable. One deviation was found in 16 cases, two deviations were identified in 3 cases and three deviations were noted in 1 case. The most frequently observed deviation was missing the rules for determining point A (10 cases). The items described by quantitative values, such as prescribed doses, certain time intervals and overall treatment time, were well followed. The proportion of deviations gradually decreased during the ICR process.
Conclusions: The present ICR demonstrated the favorable radiotherapy compliance with the JAROG0401/JROSG04-2 protocol. The QA process using ICRs can potentially be used to improve the quality of radiotherapy, including HDR-ICBT in the multi-institutional prospective studies for cervical cancer.
Key Words: cervical cancer • radiotherapy • quality assurance • clinical trial