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Japanese Journal of Clinical Oncology Pages 585-587


Editorial

Editorial

EARLY DETECTION OF GASTRIC ADENOCARCINOMA: THE KEY TO REDUCE MORTALITY OR AN ILLUSION ?

A recent paper by Everett and Axon in The Lancet arguing the significance of early gastric cancer (EGC) might cause dangerous misunderstandings for Japanese readers (1). As the reduction in gastric cancer mortality remains vitally important in our country, other relevant information should be considered before we reach such conclusions.

The authors suggested several reasons why some types of EGC might be a `pseudo-disease'. First, the diagnosis of intramucosal well differentiated adenocarcinoma is sometimes based on structural and cellular atypia, without any invasion into the lamina propria. Such cases would be diagnosed as severe dysplasia by many Western pathologists. Second, the reported doubling time of EGC is much longer than that of advanced cancer. Third, the few reports available regarding the natural history of EGC showed that one third of cases remained `early' for an average of 29 months, and 50% and 10% of patients survived more . . . [Full Text of this Article]

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