| Japanese Journal of Clinical Oncology | Pages |
Editorial
EARLY DETECTION OF GASTRIC ADENOCARCINOMA: THE KEY TO REDUCE MORTALITY OR AN ILLUSION ?
A recent paper by Everett and Axon in The Lancet arguing the significance of early gastric cancer (EGC) might cause dangerous misunderstandings for Japanese readers (1). As the reduction in gastric cancer mortality remains vitally important in our country, other relevant information should be considered before we reach such conclusions.
The authors suggested several reasons why some types of EGC
might be a `pseudo-disease'. First, the diagnosis of intramucosal
well differentiated adenocarcinoma is sometimes based on
structural and cellular atypia, without any invasion into the
lamina propria. Such cases would be diagnosed as severe
dysplasia by many Western pathologists. Second, the reported
doubling time of EGC is much longer than that of advanced
cancer. Third, the few reports available regarding the natural
history of EGC showed that one third of cases remained `early'
for an average of 29 months, and 50% and 10% of patients
survived more