Japanese Journal of Clinical Oncology

To the Editor:

The 27th International Symposium of the Princess Takamatsu Cancer Research Fund brought together scientists from several countries to present their work related to the title "Fundamentals of Cancer Prevention". The recently published proceedings from that symposium (1) included introductory remarks in which Dr T. Sugimura discussed the "Sufficiency Principle", citing Rothman's paper (2), for the multi-factorial nature of gastric cancer (3). Figure 1A in that paper shows how various carcinogenic factors cause sufficient genetic damage to convert normal cells into cancer cells, Fig.1B indicates the reduction of carcinogenic risk factors, and Fig.1C represents the summation of reductions, leading to "insufficiency" of genetic alterations (3, 4, 5).

Because of the subject matter of the proceedings, it struck me that the Sufficiency Principle might be viewed from the opposite direction, i.e. from the perspective of the preventive agent . . . [Full Text of this Article]

References

The Pre-conceived British Beliefs of Gastric Cancer in Japan Need to be Changed

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