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Japanese Journal of Clinical Oncology 30:213-214 (2000)
© 2000 Foundation for Promotion of Cancer Research

Effects of Interferon Therapy on Inhibition of Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis C

Yasushi Shiratori, Haruhiko Yoshida and Masao Omata

Department of Gastroenterology, University of Tokyo, Tokyo, Japan

The natural history of chronic HCV infection suggests that there is a sequential but slow progression from acute HCV infection to chronic infection, leading to cirrhosis and death from either liver failure or hepatocellular carcinoma (HCC) (1–4). Although chronic hepatitis, cirrhosis and HCC are accepted sequelae, the rate of development of decompensation and/or HCC to which they contribute to mortality are not well known. Because prospective studies with long-term observation are rare, only data from selected cases or studies gathered over relatively short-follow up periods have been collected.

After the introduction of interferon (IFN) for chronic hepatitis C . . . [Full Text of this Article]


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