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Japanese Journal of Clinical Oncology 32:483-487 (2002)
© 2002 Foundation for Promotion of Cancer Research

Poly(ADP-ribose) Polymerase and Cancer: In Relation to the Lectures Presented by Dr Gilbert de Murcia

Mitsuko Masutani1 and Masanao Miwa2,+,§

1 Biochemistry Division, National Cancer Center Research Institute, Tokyo and 2 Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

The first 150 words of the full text of this article appear below.


   BRIEF INTRODUCTION TO POLY(ADP-RIBOSE) POLYMERASE
 
Throughout the process of carcinogenesis, the cellular responses to DNA damage play an important role in converting normal cells into a malignant state. Poly(ADP-ribose) synthesis is one such cellular DNA damage response, as illustrated in Fig. 1. Poly(ADP-ribose) polymerase-1 (PARP-1) polyADP-ribosylates PARP-1 itself and nuclear proteins, using nicotinamide adenine dinucleotide (NAD) as a substrate. The role of PARP-1 in DNA strand breaks (1,2) and base excision repair (3) has been reported. In addition, the role of PARP-1 in the induction of necrotic cell death through cellular NAD depletion after excessive DNA damage has been described (4). PARP-1 is also involved in transcriptional control (5) and cellular differentiation (6). PARP-1 deficiency has been shown to be a risk factor for carcinogenesis in mice after treatment with alkylating agents (7) or in the combination of a deficiency . . . [Full Text of this Article]


   THE LECTURES BY DR GILBERT DE MURCIA
 

   REMARKS
 

   Acknowledgements
 

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