Japanese Journal of Clinical Oncology 2006 36(3):185; doi:10.1093/jjco/hyi248
© 2006 Foundation for Promotion of Cancer Research
A Case of T1 Sigmoid Colon Cancer with Lymph Node Involvement
Seiji Ishiguro and
Seiichiro Yamamoto
Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan
A 58-year-old man was referred to our institution for further examination of a positive fecal-occult-blood test. Colonoscopy showed a small, slightly reddish, depressed-type lesion with marginal elevation (IIa+IIc) in the sigmoid colon (Fig. 1). Subsequent chromoendoscopic evaluation spraying 0.2% indigocarmine dye revealed a clearly demarcated depression in the central part of the tumor. Crystal violet staining with a magnified view identified an irregular pit pattern in the demarcated area corresponding to an invasive pattern (Fig. 2). This tumor was diagnosed as having invasion into the submucosal layer. Therefore, endoscopic mucosal resection was not indicated. A biopsy sample demonstrated a well-differentiated adenocarcinoma. There was no evidence of lymph node or distant metastasis on computed tomography scan. A laparoscopic-assisted sigmoidectomy with D2 lymph node dissection was performed successfully. Histopathological study revealed a well-differentiated adenocarcinoma. The tumor was 6 mm in diameter and tumor extension was within the submucosal layer, 4000 µ in depth. There was a lymphatic invasion in the submucosal layer, and two metastatic lymph nodes (one in the pericolic node and the other along the feeding vessels) were found. The patient received adjuvant chemotherapy with 5-FU and leucovorin and is enjoying his life with no sign of recurrence 32 months after the operation. (Please note that colour versions of Figures 1 and 2 are available as supplementary data at http://www.jjco.oxfordjournals.org).

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