Japanese Journal of Clinical Oncology 2006 36(9):608; doi:10.1093/jjco/hyl104
© 2006 Foundation for Promotion of Cancer Research
A Case of Intrahepatic Cholangiocarcinoma Involving the Proper Hepatic Artery
Satoshi Nara and
Yoshihiro Sakamoto
Hepatobiliary and Pancreatic Surgery Division National Cancer Center HospitalTokyo, Japan
A 62-year-old male with hepatitis C viral infection, underwent an annual check up in a previous hospital. Computed tomography (CT) revealed a nodule, 3 cm in diameter, in the lateral segment of the liver, which was diagnosed as a hepatocellular carcinoma. He underwent radiofrequency ablation therapy (RFA) twice; however, the tumor developed local recurrence one year after the last RFA. He was referred to us for the treatment of the local recurrence of the tumor. Enhanced CT scan showed an irregularly shaped nodule, 4 cm in diameter, located in segments III and IV of the liver, accompanied with dilatation of the intrahepatic bile duct (Fig. 1, arrow head). The low-density area of the tumor spread along the left hepatic artery to the proper hepatic artery (Fig. 1, black arrow), suggesting an intrahepatic cholangiocarcinoma with perineural extension along the hepatic artery.
Extended left hemihepatectomy combined with resection of the
extrahepatic bile duct was performed. The proper and left hepatic
arteries were removed en bloc with the specimen. The gastroduodenal
artery (
Fig. 1, white arrow), the right hepatic artery and the
common hepatic artery were divided to secure adequate surgical
margins. The right hepatic artery (
Fig. 2, white arrowhead)
was anastomosed to the right gastroepiploic artery (
Fig. 2,
black arrowhead) under microscope. The postoperative course
was uneventful. The pathological examination revealed moderately
differentiated intrahepatic cholangiocarcinoma with massive
perineural invasion. The surgical margin was negative.

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