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Japanese Journal of Clinical Oncology 2007 37(1):73; doi:10.1093/jjco/hyl159
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© 2007 Foundation for Promotion of Cancer Research

Struma Ovarii Associated with Meigs Syndrome

Takashi Uehara and Morio Sawada

Gynecology Division, National Cancer Center Hospital, Tokyo, Japan

A 67-year-old female was referred to our hospital for further evaluation and treatment of progressively increasing abdominal distention and dyspnea. Extensive examination using computed tomography (CT) demonstrated a left-sided complex ovarian mass (about 7 cm in diameter), massive ascites and bilateral hydrothorax. Serum cancer antigen 125 level increased to 2086 U/ml. Cytological examination by needle aspiration of the ascites and pleural fluid revealed no malignancy. On enhanced CT scan, the ovarian tumor showed remarkable calcification in a part of the wall (Fig. 1, arrow), and strong enhancement in the solid component. The patient had no symptom of hyperthyroidism, and her free-T3 and free-T4 values were within normal limits. Although the ovarian tumor mimicked an advanced malignancy, our preoperative diagnosis was a struma ovarri with Meigs syndrome.


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  		Figure 1.
 
We performed simple hysterectomy and bilateral salpingo-oophorectomy for diagnostic and therapeutic purposes. The final pathological examination confirmed the diagnosis of struma ovarii with benign thyroid tissue confined in the left ovary (Fig. 2; please note that a color version of Fig. 2 is available as supplementary data at http://www.jjco.oxfordjournals.org). After surgery, the massive ascites and hydrothorax diminished completely, and CA125 level decreased to 25 U/ml.


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  		Figure 2.
 


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This Article
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