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Japanese Journal of Clinical Oncology 2007 37(8):637; doi:10.1093/jjco/hym110
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© 2007 Foundation for Promotion of Cancer Research

A Case of Endocrine Cell Carcinoma of the Gallbladder

Noriaki Morofuji and Tomoo Kosuge

Hepatobiliary and Pancreatic Surgery Division
National Cancer Center Hospital
Tokyo, Japan

A 63-year-old man underwent an annual check up in a previous hospital. Abdominal ultrasonography (US) revealed a solid tumor at the hepatic hilum. He was referred to our institute for further evaluation and treatment of the tumor. Dynamic computed tomography (CT) revealed a well-demarcated, homogeneous, enhanced tumor at the hepatic hilum in conjunction with the gallbladder (Fig. 1; a color version of this figure is available as supplementary data at http://www.jjco.oxfordjournals.org). On the US scan, the tumor was hypo-echoic and was separated from the neck of the gallbladder by a hyper-echoic layer (Fig. 2). Serum CEA and CA19-9 level were within normal limits. On the CT and US scan, the tumor originated from the gallbladder, the extrahepatic bile duct or the duodenum, but was not typical as biliary adenocarcinoma. As a result of an US-guided percutaneous biopsy, the tumor was preoperatively diagnosed as endocrine cell tumor of the gallbladder, and we conducted surgical resection.


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At laparotomy, the tumor was located at the neck of gallbladder. We performed cholecystectomy and regional lymph node dissection. The final pathological examination confirmed the diagnosis of carcinoid tumor of the gallbladder with no lymph node metastasis. On immunohistochemical examination, the tumor was stained for Chromogranin A and Synaptophysin. The Ki-67 Labeling Index was 2%.


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This Article
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