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Japanese Journal of Clinical Oncology 2008 38(6):455; doi:10.1093/jjco/hyn039
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© The Author (2008). Published by Oxford University Press. All rights reserved

A Case of Multiple Hepatic Metastases from Pancreatic Endocrine Carcinoma

Daisuke Ban and Minoru Esaki

Hepatobiliary and Pancreatic Surgery division
National Cancer Center Hospital
Tokyo, Japan

A 35-year-old man was referred to our hospital for the treatment of pancreatic and multiple hepatic tumors. Contrast computed tomography (CT) revealed a pancreatic tumor measuring 6 cm in diameter and five hepatic tumors sized from 1 to 12 cm in diameter (Figs 1 and 2). Both of the hepatic and pancreatic tumors had similar characteristics on the CT image showing well-demarcated hypervascular lesions with central low-density area. He had no endocrinopathies, but an excisional biopsy of the hepatic tumor in the previous hospital revealed endocrine carcinoma. Our diagnosis was nonfunctioning endocrine carcinoma of the pancreatic body with multiple hepatic metastases. We conducted an aggressive surgical resection of the primary and metastatic lesions, because endocrine tumors sometimes show slow-growing behaviors and curative resection might offer favorable prognosis.


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He underwent distal pancreatectomy and five limited resections of the liver. The histological examination of the resected specimens demonstrated well-differentiated endocrine carcinoma with negative surgical margins. However, he developed multiple recurrences in the remnant liver 3 months after the surgery and underwent transcatheter chemo-embolization therapy.


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This Article
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