Japanese Journal of Clinical Oncology 18:195-201 (1988)
© 1988 Foundation for Promotion of Cancer Research
research-article |
The Incidence of Secondary Tumors of the Heart and Pericardium: A 10-Year Study
1Pathology Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104
2Internal Medicine, National Cancer Center Hospital 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104
* For reprints and all correspondence
Received December 25, 1987; accepted March 10, 1988
Secondary tumors of the heart and pericardium are much more common than primary tumors. During a 10-year period (1976–1985), only one instance of a primary tumor (malignant mesothelioma) was identified among 2,649 autopsies of malignant tumors at the National Cancer Center Hospital. In contrast, there were 407 cases in which heart and/or pericardium were secondarily involved with a malignant tumor from other organs. In 78 cases, the secondary tumors were present only in the pericardium, while in 329 cases, the tumors involved the heart itself with or without pericardial involvement. Among the primary tumors, three-quarters were carcinomas of various organs. In addition there were 53 hematologic malignancies, 19 melanomas and 17 sarcomas. In 31 cases, cardiac failure was the direct cause of death. The secondary tumors of the heart were often overlooked clinically because the cardiac dysfunction appeared to be part of the deteriorating general condition. Electrocardiography and echocardiography were often helpful in suggesting the presence of cardiac metastases. Appropriate diagnostic procedures and therapeutic intervention should be considered for the care of patients with advanced malignancy and sudden onset of cardiac failure.
Key Words: Heart • Pericardium • Metastatic tumors • Electrocardiography • Echocardiography
3Current address: Internal Medicine, Tochigi Cancer Center, Utsunomiya.
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