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Japanese Journal of Clinical Oncology 21:346-352 (1991)
© 1991 Foundation for Promotion of Cancer Research

research-article

Chemotherapy of Soft Tissue Sarcomas in the Extremities

Akihiro Sudo*, Shuichi Fujinami, Yasuo Shiokawa and Yoshio Ogihara

Department of Orthopaedic Surgery, Mie University School of Medicine 2-174 Edobashi, Tsu 514

*For reprints and all correspondence

Received September 17, 1990; accepted May 20, 1991

A retrospective study on chemotherapy against soft-tissue sarcomas in the extremities was carried out on 98 patients. The local recurrence rate was 10.3% with intensive chemotherapy in post-1980 patients with high-grade sarcomas but 46.7% without chemotherapy—a fairly significant difference (P<0.01). The survival rate was significantly higher with intensive chemotherapy in post-1980 patients with high-grade sarcomas. Thus, intensive chemotherapy based on a new protocol should be given in cases of high-grade sarcoma. Considering surgical margin, the local recurrence rate was 33.3% in post-1980 cases inadequately operated upon but 8.6% in those adequately operated upon, which shows a significant difference (P<0.05).

Key Words: Soft tissue sarcoma • Chemotherapy • Recurrence • Survival


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