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Japanese Journal of Clinical Oncology, Vol 28, Issue 1 42-46, Copyright © 1998 by Foundation for Promotion of Cancer Research

ORIGINAL ARTICLE

Breast cancer in Cowden's disease: a case report with review of the literature

Y Tsubosa, T Fukutomi, H Tsuda, Y Kanai, S Akashi-Tanaka, T Nanasawa, G Linuma and K Ushio
Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan.

We report a case of invasive breast cancer in a 62-year-old female patient with Cowden's disease. A left modified radical mastectomy was performed and histopathology of the tumor showed invasive ductal carcinoma, histological grade 3, without lymph node metastasis. The patient had a past history of endometrial cancer at 55 but did not have a family history of malignant disease. Goiter was palpable but aspiration cytology revealed no malignancy. There were several papillomas on the oral mucosa and multiple papillomatous lesions on the right femur. Barium X-ray and endoscopic examination revealed multiple, small, hyperplastic polypoid lesions on the esophagus, stomach and rectum. Histopathology of the biopsy specimens from the esophagus and stomach showed acanthotic squamous epithelium and foveolar hyperplastic polyps. The patient was followed up closely to monitor the thyroid lesions and polyposis of the digestive tract. A total of 12 breast cancer patients who also had Cowden's disease have been reported in Japan and these cases are reviewed in this report.
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