Japanese Journal of Clinical Oncology, Vol 28, Issue 10 604-608, Copyright © 1998 by Foundation for Promotion of Cancer Research
M Sakamoto and S Hirohashi
BACKGROUND: The natural history and posttherapeutic outcome of adenomatous
hyperplasia and early hepatocellular carcinoma have rarely been analyzed.
METHODS: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or
early hepatocellular carcinoma and followed up for more than 6 months and
141 patients with single early hepatocellular carcinoma treated by surgical
resection or ethanol injection were collected retrospectively and analyzed.
RESULTS: Some of the adenomatous hyperplasias developed to early and to
advanced hepatocellular carcinoma. Tumors tended to grow faster in the
order adenomatous hyperplasia, early hepatocellular carcinoma and advanced
hepatocellular carcinoma, with respective mean (SD) tumor volume doubling
times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival
rates at 5 years in 53 patients treated by surgery and 88 patients treated
by ethanol injection were 89.6 and 71.9%, respectively. CONCLUSION:
Progression of adenomatous hyperplasia and early HCC was confirmed
pathologically. Early HCC was shown to have a good prognosis.
ORIGINAL ARTICLE
Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
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