Japanese Journal of Clinical Oncology, Vol 28, Issue 10 615-620, Copyright © 1998 by Foundation for Promotion of Cancer Research
H Nakayama, H Enzan, E Miyazaki, K Naruse, H Kiyoku and M Hiroi
BACKGROUND: In order to elucidate the significance of myofibroblasts in
invasive growth of colorectal adenocarcinomas, we examined the number of
myofibroblasts at the tumor border of colorectal adenocarcinomas. METHOD: A
total of 91 invasive colorectal adenocarcinomas were examined
immunohistochemically using anti-alpha-smooth muscle actin (ASMA) and
high-molecular-weight caldesmon (h-CD) antibodies; 25 carcinomas confined
to the submucosa (sm carcinomas), 40 carcinomas confined to the muscularis
propria (mp carcinomas) and 26 carcinomas invading the subserosa or
adventitia (ss carcinomas). We considered ASMA-positive and h-CD-negative
stromal cells as myofibroblasts. RESULTS: Twenty-seven (67%) of the 40 mp
carcinomas and 25 (96%) of the 26 ss carcinomas had a small number of
myofibroblasts at the tumor border facing the muscularis propria.
CONCLUSIONS: Although direct evidence is lacking, there is a possibility
that the further immediately vertical and radial invasion of carcinoma
cells into the subserosa or adventitia is associated with a smaller number
of myofibroblasts at the tumor border facing the muscularis propria in mp
carcinomas, resulting in a low incidence of mp and a high incidence of ss
carcinomas in the colorectum.
ORIGINAL ARTICLE
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas
First Department of Pathology, Kochi Medical School, Japan. nakayamh@kochi-ms.ac.jp
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