| Japanese Journal of Clinical Oncology | Pages |
Editorial
How can we predict and prevent the occurrence of therapy-related Leukemias ?
Ryuzo Ueda, Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
Advances in the fields of chemotherapy and radiotherapy have improved the survival period of cancer patients over the last few decades. Unfortunately, an unpredicted disaster has also resulted from this medical progress, the `therapy-related leukemia (TRL)' which is increasingly a focus of attention for oncologists (1). It was initially described by hematologists, particularly among long-term survivors from Hodgkin's disease, whose treatment regimens included alkylating agents and combined-modality therapy using chemotherapy and radiotherapy. Based on accumulated experience, treatment regimens for Hodgkin's disease have been changed with the