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Japanese Journal of Clinical Oncology, Vol 29, Issue 8 374-377, Copyright © 1999 by Foundation for Promotion of Cancer Research

ORIGINAL ARTICLE

Analysis of myelodysplastic syndrome clones arising after multiple myeloma: a case study by correlative interphase cytogenetic analysis

Y Kobayashi, M Nakayama, N Uemura, K Takeyama, K Tobinai, T Takenaka, SH Choi, H Satoh, S Mori and S Asano
Department of Hematology/Oncology, Institute of Medical Science, The University of Tokyo, Japan. ykkobaya@gan2.ncc.go.jp

BACKGROUND: A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. METHODS: A correlative interphase study by fluorescence in situ hybridization (FISH) was performed and we determined whether each lineage of cells obtained the molecular mark. The chromosome 9 classic alpha satellite region DNA was used as a probe for the FISH analysis in smear specimens stained with Wright-Giemsa stain. RESULTS: Erythroblasts, granulocytes and myelocytes had only one signal, whereas myeloma cells showed two to four signals. CONCLUSION: This study visualized the spectrum of MDS clone. The results suggest that the origin of MDS is different from that of multiple myeloma, at least in this case.
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