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Japanese Journal of Clinical Oncology 3:95-98 (1973)
© 1973 Foundation for Promotion of Cancer Research

Evaluation of 3,3'-Iminodi-l-Propanol, Dimethane-Sulfonate (Ester), p-Toluenesulfonate No. 864 T (NSC: 140117) in the Treatment of Chronic Myeloid Leukemia

NAZLY GAD-EL-MAWLA, M.D., MUSTAFA ABUL-ENIEN, M.D., MOHMED R. HAMZA, M.D., MAHMOUD M. EL-MERZABANI, PH.D.* and AHMED L. ABUL-NASR, M.D.

Cancer Institute, Cairo University Egypt
* Cancer Institute, Japanese Foundation for Cancer Research Tokyo, Japan

Received July 24, 1973; The antileukemic effect of No. 864 T was evaluated in twelve Egyptian patients suffering from chronic myeloid leukemia. Response was encountered in ten cases, and two were resistant. Remission lasted four months in one case, seven to eight months in five cases, 12 months in one case, 17–19 months in two cases (still in remission) and one case not followed.

No. 864 T proved to have clinical value in the treatment of myleran resistant cases; seven out of nine cases resistant to myleran responded to No. 864 T. Significant difference in the activities of No. 864 and No. 864 T was not observed at least as far as the remission rate is concerned on chronic myeloid leukemia patients and side effects.


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