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Japanese Journal of Clinical Oncology 30:17-20 (2000)
© 2000 Foundation for Promotion of Cancer Research

Multidisciplinary Approach to Wilms’ Tumor: 18 Years of Experience

Inci Yildiz, Lebriz Yüksel, Alp Özkan, Hilmi Apak, Tiraje Celkan, Nur Danismend, Cenk Büyükünal, Yunus Söylet, Nüvit Sarimurat, Sergülen Dervisoglu, Figen Aksoy, Gülyüz Atkovar and Sait Okkan+

Cerrahpasa Medical Faculty, Department of Paediatric Haematology–Oncology, University of Istanbul, Istanbul, Turkey

Background: The aim was to evaluate the characteristics of Wilms’ tumor and the results of combined modality treatment obtained in our center in Turkey.

Methods: From January 1978 to December 1996, 106 patients with Wilms’ tumor were diagnosed. Of these 106 patients, 61 were male and 45 were female (M/F = 1,35); the median age at diagnosis was 39 months. The distribution of the 106 patients according to clinical stage was stage I 10%, stage II 42%, stage III 35%, stage IV 9% and stage V 4%. Histologically, 102 of the cases could be evaluated: favorable histology was diagnosed in 88.2% and unfavorable histology in 11.8% of the patients. Ninety-eight patients were treated according to NWTS and eight patients according to SIOP protocols.

Results: The EFS and overall survival rates at 2 years were 74.2 and 79.5% respectively, and at 5 years 72.4 and 76.6% respectively.

Conclusion: As a developing country we evaluated our survival rates and report an improvement in treatment in recent years.

+ For reprints and all correspondence: Alp Özkan, Suadiye Kavisli Sokak, Fidan Apt. No. 15/13, 81070 Istanbul,Turkey. E-mail: alpok @ superonline.comAbbreviations: NWTS, National Wilms’ Tumor Study; SIOP, International Society of Pediatric Oncology; UKW, United Kingdom Wilms’ Tumor Trial; EFS, event-free-survival; CT, computed tomography; MRI, magnetic resonance imaging


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