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Japanese Journal of Clinical Oncology 30:453-457 (2000)
© 2000 Foundation for Promotion of Cancer Research

Changes in Findings of Mammography, Ultrasonography and Contrast-enhanced Computed Tomography of Three Histological Complete Responders with Primary Breast Cancer Before and After Neoadjuvant Chemotherapy: Case Reports

Toru Nakamura1, Takashi Fukutomi1, Hitoshi Tsuda2, Sadako Akashi-Tanaka1, Kaneyuki Matsuo1, Chikako Shimizu1 and Kunihisa Miyakawa3,+

1Breast Surgery Division, National Cancer Center Hospital, Tokyo, 2Pathology Division, National Cancer Center Research Institute, Tokyo and 3Diagnostic Radiology Division, National Cancer Center Hospital, Tokyo, Japan

We report the changes in the findings of imaging examinations (mammography, ultrasonography and contrast-enhanced computed tomography) of three patients with primary breast cancer before and after neoadjuvant chemotherapy, who obtained histologically complete responses after the chemotherapy. The neoadjuvant chemotherapy consisted of four cycles of doxorubicin and docetaxel. All patients were clinically judged as partial responders, because of the remaining tumorous lesions in the imaging examinations. However, these tumorous lesions could be related to the chemotherapy-induced fibrosis and tumor necrosis or the remaining fibrocystic changes. In this study, it was considered very difficult to estimate the extent of residual tumors accurately in patients with primary breast cancer after neoadjuvant chemotherapy by any type of imaging examination.

+ For reprints and all correspondence: Takashi Fukutomi, Department of Surgical Oncology, National Cancer Center Hospital, 1–1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan


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