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Japanese Journal of Clinical Oncology 30:263-266 (2000)
© 2000 Foundation for Promotion of Cancer Research

Blue Nodes Left Behind After Vital Blue Dye-guided Axillary Sentinel Node Biopsy in Breast Cancer Patients

Gábor Cserni1, Mária Rajtár2 and Gábor Boross1,+

Departments of 1Surgical Pathology and 2Nuclear Medicine and Surgery, Bács-Kiskun County Teaching Hospital affiliated to the Albert Szent-Györgyi Medical University, Kecskemét, Hungary

Background: Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas.

Methods: From a series of 112 successful sentinel lymph node biopsies with Patent Blue dye followed by axillary dissection, 10 cases were identified where 1–3 blue nodes were found in the axillary dissection specimens. These 10 cases were compared with those which had all blue nodes identified during surgery. Five of the 10 patients with missed blue nodes also underwent lymphoscintigraphy with 99m-Tc-labeled colloidal human albumin and all of their nodes were subjected to external gamma well counting postoperatively.

Results: There were six false-negative sentinel lymph node biopsies overall, but none in patients with missed blue nodes. Patients with primarily unidentified blue nodes had more sentinel nodes and a higher rate of multiple sentinel nodes than the others.

Conclusion: Blue nodes missed during surgery may be either true sentinel nodes or second echelon nodes labeled by dye overflow. This type of error may occur in <8% of patients and may lead to false-negative sentinel node-based staging in an even smaller proportion of cases (none in this series).

+ For reprints and all correspondence: Gábor Cserni, Department of Surgical Pathology, Bács-Kiskun County Teaching Hospital affiliated to the Albert Szent-Györgyi Medical University, Nyíri út 38, H-6000 Kecskemét, Hungary. E-mail: cserni@freemail.c3.hu


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G. Cserni
Commentary on in-transit lymph node metastases in breast cancer: a possible source of local recurrence after Sentinel Node procedure
J. Clin. Pathol., December 1, 2008; 61(12): 1233 - 1235.
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