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Japanese Journal of Clinical Oncology 30:267-271 (2000)
© 2000 Foundation for Promotion of Cancer Research

Six-year Disease-free Survival of a Patient with Metastatic Eyelid Squamous Cell Carcinoma and Colon Adenocarcinoma after Repeated Postoperative Adoptive Immunotherapy

Akiyoshi Kawamura Jr1, Teruaki Sekine2, Morimasa Sekiguchi3, Shunsuke Yanoma4, Akihiro Kaneko5, Tatsumasa Haneda6, Yoshihiro Moriya7, Ken-ichi Hayasaka8 and Tadao Kakizoe9,+

1Department of Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, 2RI Laboratory, National Cancer Center Research Institute, Tokyo, 3Department of Surgery I, Saitama Medical School, Saitama, 4Kanagawa Cancer Center, Clinical Research Institute, Yokohama, 5Ophthalmology Division, 6Head and Neck Surgery and Plastic Surgery Division, 7Colorectal Surgery Division and 9Director, National Cancer Center Hospital, Tokyo and 8Dermatology Division, Kawasaki-Saiwai Clinic, Kawasaki, Japan

A 74-year-old male was affected concurrently with squamous cell carcinoma of the left eyelid and adenocarcinoma of the colon, both with lymph node metastasis. He underwent exenteration of the left orbit with left modified radical neck dissection and subsequently resection of the transverse colon with regional lymph node dissection. The patient has been treated by an adoptive immunotherapy as a sole postoperative modality without receiving any chemotherapeutic agents causing immunosuppression. For the adoptive immunotherapy, autologous peripheral blood lymphocytes were activated with an immobilized anti-CD3 antibody and IL-2 for 14 days (the CD3-AT cells). The infusion with 1.38 x 1010 CD3-AT cells has been repeated 150 times in total at the time of writing. Neither recurrence nor additional metastasis has been detected for 6 years after surgery.

+ For reprints and all correspondence: Tadao Kakizoe, Director, National Cancer Center Hospital, 5–1–1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan


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