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Japanese Journal of Clinical Oncology 30:406-409 (2000)
© 2000 Foundation for Promotion of Cancer Research

A Case of Inoperable Esophageal Carcinoma with Hepatic and Nodal Metastases Which Showed a Long-term Survival after Chemoradiotherapy Including Nedaplatin

Hajime Sumi1, Atsushi Ohtsu1, Narikazu Boku1, Manabu Muto1, Fumio Nagashima1, Koichi Hosokawa1, Sigeaki Yoshida1, Mitsuo Satake2, Satoshi Ishikura2 and Takashi Ogino2

,+ 1Division of Gastrointestinal Oncology/Gastroenterology, and 2Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

We report a case of metastatic esophageal carcinoma successfully treated with chemoradiotherapy. A 61-year-old man, diagnosed as suffering from advanced esophageal carcinoma with liver and lymph node metastases, was treated with a combination of nedaplatin (90 mg/m2/day, 1 h drip infusion, day 1), 5-fluorouracil (800 mg/m2/day, continuous infusion, days 1–5), and radiotherapy (2 Gy/day, days 1–5, 8–12 and 15–19). The cycle was repeated twice every 5 weeks from July 2, 1997. He achieved a complete response 1 month after finishing two courses of chemoradiotherapy followed by an additional three courses of chemotherapy without radiation. Seven months after the completion of radiotherapy, pericardial effusion with negative cytology was recognized. The effusion was treated by pericardiocentesis and drainage for ­several days. After drainage, the effusion could be easily managed with diuretics. This patient is still alive with no evidence of disease more than 2.5 years after the initiation of the treatment.

+ For reprints and all correspondence: Hajime Sumi, Division of Gastrointestinal Oncology/Gastroenterology, National Cancer Center Hospital East, 6–5–1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. E-mail: hsumi@east.ncc.go.jp


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