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Japanese Journal of Clinical Oncology 31:209-211 (2001)
© 2001 Foundation for Promotion of Cancer Research

Pulmonary Amyloidosis Diagnosed by CT-guided Transbronchial Biopsy: a Case Report

Hiroshi Kitamura1, Toshiaki Kobayashi1, Masamitsu Kaneko1, Masahiko Kusumoto2, Tetsuro Kodama3, Yoshihiro Matsuno4 and Toshio Niki5,+

1Endoscopy Division, 2Diagnostic Radiology Division, 3Medical Oncology Division and 4Clinical Laboratories Division, National Cancer Center Hospital, Tokyo and 5Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

During a medical check-up, a nodular shadow was detected by chest X-ray in the right lower lung field of a 59-year-old man. On computed tomography (CT), the nodular lesion had a relatively well-defined, irregular margin. A fluoroscopy-guided bronchoscopic biopsy did not uncover any malignancy. Specimens from a subsequent CT-guided bronchoscopic biopsy revealed a pulmonary amyloid deposit. As a rule, it is difficult to exclude malignancy or confirm benign disease in cases of truly benign lesions, particularly if the lesions are difficult to biopsy. Amyloidosis is one of such conditions and requires reliable diagnostic methods to avoid unnecessary surgical resection. From our experience, we consider CT-guided bronchoscopic biopsy to be a safe and accurate procedure, even when applied to truly benign lesions.

+ For reprints and all correspondence: Toshiaki Kobayashi, Endoscopy Division, National Cancer Center Hospital, 1–1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan


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