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Japanese Journal of Clinical Oncology 31:221-225 (2001)
© 2001 Foundation for Promotion of Cancer Research

Colon Cancer with Meningeal Carcinomatosis and Myelodysplastic Syndrome in a Patient Who Underwent Intensive Chemotherapy for Acute Myelogenous Leukemia: a Case Report

Takahiro Nagashima1,2, Kazuo Muroi1,2, Masae Kunitama1, Tohru Izumi1, Tetsuya Ohtsuki1, Norio Komatsu1, Masashi Fukayama3 and Keiya Ozawa1,2,+,§

1Division of Hematology, Department of Medicine, 2Division of Cell Transplantation and Transfusion and 3Department of Pathology, Jichi Medical School, Tochigi, Japan

A 59-year-old man was admitted to our hospital because of disturbance of consciousness and hyponatremia. The patient had suffered from acute myelogenous leukemia (AML) with 46,XY and received chemotherapy for 5 years. Meningeal carcinomatosis was diagnosed due to the detection of carcinoma cells in the cerebrospinal fluid (CSF). Hyponatremia was caused by syndrome of inappropriate secretion of anti-diuretic hormone (SIADH). Bone marrow examination revealed myelodysplastic syndrome (MDS) with deletion of the long arm of chromosome 7. Emergence of a new abnormal clone was suggested. The patient died from brain herniation. Post mortem examination showed adenocarcinoma in the colon. An association between chemotherapy and both colon cancer and MDS was suggested.

+ For reprints and all correspondence: Takahiro Nagashima, Division of Cell Transplantation and Transfusion, Jichi Medical School, 3311–1 Yakushiji, Minamikawachi-Machi, Kawachi-Gun, Tochigi 329-0498, Japan. E-mail: tnag@jichi.ac.jp

§ Abbreviations: AML, acute myelogenous leukemia; CSF, cerebrospinal fluid; SIADH, syndrome of inappropriate secretion of anti-diuretic hormone; MDS, myelodysplastic syndrome; CT, computed tomography; LDH, lactate dehydrogenase; CEA, carcinoembryonic antigen; PAS, periodic acid–Schiff; MRI, magnetic resonance imaging


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