Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Feng, H.
Right arrow Articles by Araki, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feng, H.
Right arrow Articles by Araki, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Japanese Journal of Clinical Oncology 32:525-529 (2002)
© 2002 Foundation for Promotion of Cancer Research

Expression of MUC1 and MUC2 Mucin Gene Products in Human Ovarian Carcinomas

Hong Feng1, Mohammad Ghazizadeh2, Hideki Konishi1 and Tsutomu Araki1,+

1 Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo and 2 Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa, Japan

Background: Aberrations in expression of mucin glycoproteins have been observed during malignant transformation of human ovarian epithelium. To date, several secretory mucin genes designated the MUC gene family have been identified, of which MUC1 encodes a mammary-type and MUC2 an intestinal-type epithelial mucin. However, information on the expression and potential value of MUC1 and MUC2 mucins in ovarian cancer is limited.

Methods: This study investigated immunohistochemical expressions of MUC1 and MUC2 mucins in 23 benign and 45 malignant human ovarian tumors to assess their clinicopathological relevance.

Results: All benign serous tumors and also associated normal-appearing epithelia expressed MUC1 mucin on the cell surfaces. Benign mucinous tumors occasionally expressed MUC1 and MUC2 mucins. Most serous carcinomas (19/21; 90%) expressed MUC1 but not MUC2 mucin. Of the 16 mucinous carcinomas, 10 (62%) and five (31%) expressed MUC1 and MUC2 mucins, respectively. Four of the five clear cell and the three endometroid type carcinomas expressed MUC-1 but not MUC-2 mucin. A significant association was found between a high expression of MUC1 and histological grade (P = 0.005) and also disease stage (P = 0.001).

Conclusion: These results suggest that a high expression of MUC1 may contribute to a poor prognosis in ovarian carcinoma.

+ For reprints and all correspondence: M. Ghazizadeh, Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, 1–396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan. E-mail:ciem@nms.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
A. B. Tchagang, A. H. Tewfik, M. S. DeRycke, K. M. Skubitz, and A. P.N. Skubitz
Early detection of ovarian cancer using group biomarkers
Mol. Cancer Ther., January 1, 2008; 7(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. L. Terry, L. Titus-Ernstoff, J. R. McKolanis, W. R. Welch, O. J. Finn, and D. W. Cramer
Incessant Ovulation, Mucin 1 Immunity, and Risk for Ovarian Cancer
Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 30 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. S. de Bono, S. Y. Rha, J. Stephenson, B. C. Schultes, P. Monroe, G. S. Eckhardt, L. A. Hammond, T. L. Whiteside, C. F. Nicodemus, J. M. Cermak, et al.
Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity
Ann. Onc., December 1, 2004; 15(12): 1825 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Hibbs, K. M. Skubitz, S. E. Pambuccian, R. C. Casey, K. M. Burleson, T. R. Oegema Jr, J. J. Thiele, S. M. Grindle, R. L. Bliss, and A. P.N. Skubitz
Differential Gene Expression in Ovarian Carcinoma: Identification of Potential Biomarkers
Am. J. Pathol., August 1, 2004; 165(2): 397 - 414.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.