Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Ichikawa, Y.
Right arrow Articles by Yoshikawa, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ichikawa, Y.
Right arrow Articles by Yoshikawa, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Japanese Journal of Clinical Oncology 32:110-112 (2002)
© 2002 Foundation for Promotion of Cancer Research

Microsatellite Instability and Immunohistochemical Analysis of MLH1 and MSH2 in Normal Endometrium, Endometrial Hyperplasia and Endometrial Cancer from a Hereditary Nonpolyposis Colorectal Cancer Patient

Yoshihito Ichikawa, Hajime Tsunoda, Katsumi Takano, Akinori Oki and Hiroyuki Yoshikawa+

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Hereditary nonpolyposis colorectal cancer (HNPCC)-related endometrial cancer is associated with mutations in DNA mismatch repair genes. However, chronological changes of these genes in the endometrium have not been studied in women from HNPCC families. Tissue samples of normal endometrium, endometrial hyperplasia without atypia and endometrial cancer were collected at different times from a 41-year-old Japanese woman with a family history of HNPCC. Combined microsatellite instability (MSI) and immunohistochemical analysis of MLH1 and MSH2 predicted the presence of a mutation in MSH2 when she had endometrial hyperplasia without atypia 7 months before the diagnosis of endometrial cancer. Endometrial hyperplasia without atypia may indicate an early development of endometrial cancer in women from HNPCC families.

+ For reprints and all correspondence: Yoshihito Ichikawa, Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1–1–1 Tennohdai, Tsukuba, Ibaraki 305-8575, Japan. E-mail: yoichika@md.tsukuba.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
T. T. Nieminen, A. Gylling, W. M. Abdel-Rahman, K. Nuorva, M. Aarnio, L. Renkonen-Sinisalo, H. J. Jarvinen, J.-P. Mecklin, R. Butzow, and P. Peltomaki
Molecular Analysis of Endometrial Tumorigenesis: Importance of Complex Hyperplasia Regardless of Atypia
Clin. Cancer Res., September 15, 2009; 15(18): 5772 - 5783.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. S. Jones, C. I. Amos, M. Pande, X. Gu, J. Chen, I. M. Campos, Q. Wei, M. Rodriguez-Bigas, P. M. Lynch, and M. L. Frazier
DNMT3b Polymorphism and Hereditary Nonpolyposis Colorectal Cancer Age of Onset.
Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 886 - 891.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.