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Japanese Journal of Clinical Oncology 33:229-231 (2003)
© 2003 Foundation for Promotion of Cancer Research

Durable Remission of Leptomeningeal Metastasis of Breast Cancer with Letrozole: a Case Report and Implications of Biomarkers on Treatment Selection

Mustafa Ozdogan1, Mustafa Samur1, Hakan S. Bozcuk1, Ergin Sagtas2, Mustafa Yildiz1, Mehmet Artac1 and Burhan Savas1,+

1 Division of Medical Oncology, Department of Internal Medicine, Akdeniz University Medical School, Antalya and 2 Department of Radiology, Radon Medical Center, Antalya, Turkey

We report a breast cancer patient with leptomeningeal carcinomatosis (LM) who showed an excellent objective and subjective response to letrozole, with a progression-free survival of 16 months. We think that despite the poor prognosis and short survival of patients with LM, early diagnosis and treatment with appropriate hormonal manipulation may improve the outcome and achieve prolonged palliation in selected hormone-positive breast cancer patients with LM. Possible clues predicting the response were also evaluated in the context of literature data.

+ For reprints and all correspondence: Mustafa Ozdogan, Akdeniz Universitesi Tip Fakultesi, Ic Hastaliklari ABD, Onkoloji BD, Antalya, Turkey. E-mail: mustafa0051{at}hotmail.com


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