Japanese Journal of Clinical Oncology 33:302-308 (2003)
© 2003 Foundation for Promotion of Cancer Research
Phase I and Pharmacokinetic Study of KRN5500, a Spicamycin Derivative, for Patients with Advanced Solid Tumors
1 Division of Internal Medicine, National Cancer Center Hospital, Tokyo and 2 Department of Hospital Pharmacy, School of Medicine, Keio University, Tokyo, Japan
Background: KRN5500, a novel spicamycin derivative, shows an inhibitory effect on protein synthesis. This phase I study was aimed at investigating the toxicity, maximum tolerated dose (MTD) and pharmacokinetics of this compound.
Patients and methods: Patients with solid tumors not amenable to standard forms of treatment were eligible. KRN5500 was administered as a 2 h intravenous infusion every 4 weeks at doses of 3, 6, 10, 15 and 21 mg/m2. Pharmacokinetic evaluation was performed at the first cycle.
Results: Eighteen patients with advanced solid tumors were enrolled. A total of 26 cycles of KRN5500 were administered. The major toxicities were nausea, vomiting, diarrhea, fatigue and a mild reversible prolongation of prothrombin time. Grade 4 pulmonary toxicity (interstitial pneumonitis) was observed in one patient at a dose level of 15 mg/m2. Severe fatigue was observed in one patient at a dose level of 21 mg/m2 and the duration of fatigue tended to increase with the dose of KRN5500. Nausea and vomiting were frequently observed and became prolonged with increasing dose of KRN5500. These toxicity profiles were identified as unacceptable and further dose escalation above 21 mg/m2 was withheld. The MTD was therefore determined as 21 mg/m2. The peak plasma concentration and the area under the concentration–time curve of KRN5500 increased proportionally to the dose, suggesting linear pharmacokinetics. No objective antitumor response was observed.
Conclusion: KRN5500, a structurally novel protein synthesis inhibitor, warrants further investigation to overcome these toxicity profiles and improve its efficacy.
+ Abbreviations: IC50, 50% inhibitory concentration; MTD, maximum tolerated dose; DLT, dose-limiting toxicity; PK, pharmacokinetic; TP, total protein; TC, total cholesterol; AST, aspartate amino transferase; ALT, alanine amino transferase; PT, prothrombin time; APTT, activated partial thromboplastin time; Vdss, volume of distribution at steady state; AUC, area under the concentration–time curve; CL, clearance; DAD, diffuse alveolar damage
For reprints and all correspondence: Tomohide Tamura, Division of Internal Medicine, National Cancer Center Hospital, 5–1–1, Tsukiji Chuo-ku, Tokyo 104-0045, Japan. E-mail: ttamura{at}ncc.go.jp