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Japanese Journal of Clinical Oncology 2004 34(8):469-471; doi:10.1093/jjco/hyh081
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© 2004 Foundation for Promotion of Cancer Research

Short Communication

Comparison of the Effectiveness Between a Single Low Dose and Fractionated Doses of Radioiodine in Ablation of Post-operative Thyroid Remnants

Guang-Uei Hung1, Shih-Te Tu2, Iuan-Sheng Wu3 and Kwang-Tao Yang1

1 Department of Nuclear Medicine, 2 Division of Endocrinology and Metabolism, and 3 Department of Otorhinolaryngology, Changhua Christian Hospital, Changhua, Taiwan

For reprints and all correspondence: Guang-Uei Hung, Department of Nuclear Medicine, Changhua Christian Hospital, 135 Nansiao street, Changhua 500, Taiwan. E-mail: 106143{at}cch.org.tw

Received February 26, 2004; accepted May 20, 2004

Due to the lack of radiation isolation wards in most hospitals in Taiwan, high-dose (exceeding 30 mCi) radioiodine therapy is usually performed in a fractionated manner (successively administering multiple low doses). This study compared the ablating efficacies of post-operative thyroid remnants using a single low dose (30 mCi) and fractionated doses (four doses of 30 mCi given at weekly intervals) in 59 patients with differentiated thyroid cancer who received total or near-total thyroidectomy. Successful ablation was obtained in 20 of 38 patients (52.6%) treated with a single low dose compared with 14 of 21 patients (66.7%) treated in a fractionated manner. There was no statistically significant difference between these two treatment protocols (P = 0.296). As the fractionated-dose protocol has the drawbacks of a much longer hypothyroid state and a higher total expense, we suggest that a single low dose is more feasible than fractionated doses for outpatient ablation therapy.

Key Words: thyroid carcinoma • postoperative ablation • radioiodine therapy • thyroid stunning


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