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Japanese Journal of Clinical Oncology 2005 35(2):57-60; doi:10.1093/jjco/hyi019
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© 2005 Foundation for Promotion of Cancer Research

Management of Malignant Pericardial Effusion with Instillation of Mitomycin C in Non-small Cell Lung Cancer

Kyoichi Kaira1, Atsushi Takise1, Go Kobayashi1, Mitsuyoshi Utsugi1, Takeo Horie1, Takanori Mori1, Hisao Imai1, Masahito Inazawa1 and Masatomo Mori2

1 Department of Respiratory Medicine, Maebashi Red Cross Hospital and 2 Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan

For reprints and all correspondence: Kyoichi Kaira, Maebashi Red Cross Hospital, Department of Respiratory Medicine, 3-21-36, Asahi-cho, Maebashi, Gunma 377-0014, Japan. E-mail: k-kaira{at}maebashi.jrc.or.jp

Received June 20, 2004; accepted December 11, 2004

Background: To evaluate the clinical efficacy and safety of mitomycin C in the local control of malignant pericardial effusion, we carried out a trial of pericardial drainage with local instillation of mitomycin C in eight patients who suffered from cardiac tamponade or symptomatic large pericardial effusion caused by advanced non-small cell lung cancer.

Methods: After complete removal of the pericardial effusion by an ultrasound-guided inserted catheter, 2 mg of mitomycin C was instilled into the pericardial space via the catheter.

Results: The drainage catheter was successfully removed in all patients. The duration of pericardial drainage ranged from 7 to 14 days (median 10.5 days). Six of the eight patients achieved a complete remission of pericardial effusions without any adverse effects.

Conclusion: Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.

Key Words: malignant pericardial effusion • mitomycin C • lung cancer • intrapericardial instillation • pericardial drainage


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