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Japanese Journal of Clinical Oncology 2005 35(3):158-161; doi:10.1093/jjco/hyi040
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© 2005 Foundation for Promotion of Cancer Research

Cancer Genetics Report

Association of a Genetic Polymorphism of the E-cadherin Gene with Prostate Cancer in a Japanese Population

Toshiyuki Kamoto1, Yoshiaki Isogawa1, Yousuke Shimizu1, Sachiko Minamiguchi2, Hidefumi Kinoshita1, Yoshiyuki Kakehi3, Kenji Mitsumori4, Shingo Yamamoto1, Tomonori Habuchi1, Tetsuro Kato4 and Osamu Ogawa1

1 Department of Urology and 2 Department of Clinical Pathology, Kyoto University Graduate School of Medicine, Kyoto, 3 Department of Urology, Kagawa University, Takamatsu and 4 Department of Urology, Akita Medical University, Akita, Japan

For reprints and all correspondence: Osamu Ogawa, Department of Urology, Kyoto University Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto City, Kyoto 606-8507, Japan. E-mail: ogawao{at}kuhp.kyoto-u.ac.jp

Received August 26, 2004; accepted January 8, 2005

The E-cadherin gene has been identified as having a physiological role in cellular attachment, and is hypothesized to participate in carcinogenesis. A polymorphism (an A to C substitution) in the 5'-untranslated region has a direct effect on E-cadherin gene transcriptional regulation. We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. The subjects consisted of 236 patients with prostate cancer, 209 benign prostatic hyperplasia (BPH) patients and 139 male controls. A marginally significant difference was found between prostate cancer patients and male controls (P = 0.053). No significant difference was observed between prostate cancer and BPH patients. When patients with prostate cancer were divided into two groups, stage A+B and stage C+D, a significant difference was observed between progressive cancer patients (stage C+D) and male controls (odds ratio = 1.93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression.

Key Words: E-cadherin • prostate cancer • single nucleotide polymorphism


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