Japanese Journal of Clinical Oncology Advance Access originally published online on February 14, 2006
Japanese Journal of Clinical Oncology 2006 36(3):166-171; doi:10.1093/jjco/hyi233
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© 2006 Foundation for Promotion of Cancer Research
Possible Involvement of Hyperlipidemia in Increasing Risk of Colorectal Tumor Development in Human Familial Adenomatous Polyposis
1 Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, 2 Department of Surgery, National Cancer Center Hospital, Tokyo and 3 Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
For reprints and all correspondence: Michihiro Mutoh, Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1-1 Tsukiji 5-Chome, Chuo-ku, Tokyo 104-0045, Japan. E-mail: mimutoh{at}gan2.ncc.go.jp
Received September 7, 2005; accepted December 19, 2005
Background: Familial adenomatous polyposis (FAP) results from germline adenomatous polyposis coli (APC) gene mutations and many affected patients die from colorectal cancers which arise from colorectal polyps. We previously reported that two strains of Apc gene-deficient mice developing multiple intestinal polyps exhibit a hyperlipidemic state. The triglyceride (TG) levels were 
10-fold higher than the levels observed in wild-type mice.
Methods: To examine whether a positive relationship might exist between hyperlipidemia and colorectal tumor development in FAP patients, as with Apc gene-deficient mice, a pilot experiment was performed using readily available clinical data such as ages, serum lipid levels, number of colorectal polyps and cancer development in 28 FAP patients from the National Cancer Center Hospital, Japan.
Results: The overall prevalence of hyperlipidemia in FAP cases was 58%. Average TG levels in the 40–60 year age groups of FAP patients were 
150 mg/dl (the defined threshold level of hyperlipidemia). Moreover, there was a tendency for higher serum TG levels in patients who developed colorectal cancer, as compared with those without colorectal cancer.
Conclusions: These results show that a hyperlipidemic state occurs in FAP patients. Although it is weaker than that in Apc gene-deficient mice, it may be linked to colon tumor development. These data warrant further studies for wider poplulations of FAP patients.
Key Words: APC gene • colorectal cancer • familial adenomatous polyposis • hyperlipidemia
Abbreviations: BMI, body mass index • ChE, cholinesterase • COX, cyclooxygenase • FAP, familial adenomatous polyposis • LPL, lipoprotein lipase • NSAIDs, non-steroidal anti-inflammatory drugs • PPAR, peroxisome proliferator-activated receptor • TC, total cholesterol • TG, triglyceride
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