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Japanese Journal of Clinical Oncology Advance Access originally published online on May 15, 2006
Japanese Journal of Clinical Oncology 2006 36(5):325-328; doi:10.1093/jjco/hyl009
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© 2006 Foundation for Promotion of Cancer Research

Case Report

T1 Neuroendocrine Carcinoma of Anal Canal after Transanal Resection for Intramucosal Adenocarcinoma

Hirotoshi Kobayashi1, Hideki Ueno1, Yojiro Hashiguchi1, Megumi Ishiguro1, Jiro Omata1, Yoshiki Kajiwara1, Hideyuki Shimazaki2 and Hidetaka Mochizuki1

1 Department of Surgery I and 2 Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan

For reprints and all correspondence: Hirotoshi Kobayashi, Department of Surgical Oncology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. E-mail: h-kobayashi.srg2{at}tmd.ac.jp

Received December 5, 2005; accepted February 6, 2006

Neuroendocrine carcinomas of the anal canal are rare, representing 1% of malignant tumors of the anal canal. This tumor behaves aggressively and leads to poor outcomes. The majority of tumors are found with distant metastases. We describe the case of a 63-year-old female with T1 neuroendocrine carcinoma of the anal canal arising from the site of a previous transanal excision performed 13 months earlier for intramucosal adenocarcinoma of the anal canal. The patient did not have any distant metastases on preoperative computed tomography and magnetic resonance imaging. She underwent abdominoperineal resection after the initial diagnostic transanal excision of the neuroendocrine carcinoma, which had shown submucosal invasion. No lymph node metastasis was found in pathological examination. In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma.

Key Words: anal canal • colorectal carcinoma • neuroendocrine carcinoma


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