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Japanese Journal of Clinical Oncology Advance Access originally published online on August 24, 2007
Japanese Journal of Clinical Oncology 2007 37(10):793-796; doi:10.1093/jjco/hym094
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© 2007 Foundation for Promotion of Cancer Research

Granulocyte Colony-stimulating Factor Production and Rapid Progression of Gastric Cancer after Histological Change in the Tumor

Tomoki Yamano1,, Eiichi Morii2, Jun-Ichiro Ikeda2 and Katsuyuki Aozasa2

1 Department of Surgery, Kawachi General Hospital, Higashiosaka, Osaka
2 Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan

For reprints and all correspondence: Tomoki Yamano, Department of Surgery, Kawachi General Hospital, 1–31 Yokomakura, Higasi-Osaka, 578-0954, Japan. E-mail: yamanot{at}kawati.org

Received February 27, 2007; accepted June 3, 2007

Granulocyte colony-stimulating factor (G-CSF)-producing malignancies are thought to be rare and associated with advanced disease and poor prognosis. Here, we report on a 77-year-old patient with G-CSF-producing gastric cancer. We observed this patient from the stage prior to the diagnosis of gastric cancer when leukocyte count was normal to the stage of advanced disease associated with remarkable leukocytosis. Immunohistochemical analysis demonstrated G-CSF expression in the advanced-stage, poorly differentiated adenocarcinoma, but not in the early-stage, well-differentiated adenocarcinoma. G-CSF receptor was not detected to be expressed in the advanced-stage tumor. Based on these results it appears that a histological change in the tumor may influence G-CSF production and the concomitant rapid progression in gastric cancer.

Key Words: granulocyte colony-stimulating factor • gastric cancer • histology


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