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Japanese Journal of Clinical Oncology Advance Access originally published online on October 7, 2008
Japanese Journal of Clinical Oncology 2008 38(12):803-809; doi:10.1093/jjco/hyn104
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© The Author (2008). Published by Oxford University Press. All rights reserved

Chemoradiotherapy for Locally Recurrent Nasopharyngeal Carcinoma: Treatment Outcome and Prognostic Factors

Tatsuya Nakamura, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Takuya Tomoda, Rie Nakahara, Haruo Inokuchi, Nobutaka Mizoguchi, Akinori Takada and Nobukazu Fuwa

Department of Radiation Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan

For reprints and all correspondence: Tatsuya Nakamura, Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. E-mail: tatsuya.nakamura{at}nifty.com

Received July 22, 2008; accepted September 4, 2008

Objective: To evaluate the treatment outcome of patients with locally recurrent nasopharyngeal carcinoma (NPC) treated with re-irradiation and chemotherapy.

Methods: Between 1991 and 2004, 36 patients with locally recurrent NPC received re-irradiation and chemotherapy. The median re-irradiation dose was 37.9 Gy; the median total dose of prior irradiation and re-irradiation was 104.4 Gy. The outcome is studied retrospectively and also evaluated the prognostic factors and toxicities.

Results: With a median follow-up of 40 months, 3-year overall survival (OS) was 58.3% and 3-year progression-free survival (PFS) was 25.0%. Patients aged <50 and of early stage at recurrence had a significantly better OS and PFS. Over Grade 3 of late toxicities were seen in patients received a total dose of >110 Gy.

Conclusions: Age and stage at recurrence were identified as prognostic factors for OS and PFS. Patients received external beam radiation therapy at a total dose of more than 110 Gy should be careful for severe late toxicities, and it is thought to be the optimal dose for recurrent tumor.

Key Words: re-treatment • locally recurrent • nasopharyngeal carcinoma • treatment outcome • prognostic factors


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