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Japanese Journal of Clinical Oncology Advance Access originally published online on February 4, 2008
Japanese Journal of Clinical Oncology 2008 38(2):143-145; doi:10.1093/jjco/hym165
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© The Author (2008). Published by Oxford University Press. All rights reserved

Salvage Combination Chemotherapy with Docetaxel, Ifosfamide and Cisplatin (DIP): Successful Treatment of a Case with Metastatic Testicular Immature Teratoma

Haruki Kume, Shigenori Kakutani, Kyoichi Tomita and Tadaichi Kitamura

Department of Urology, Tokyo University Hospital, Bunkyo-ku, Tokyo, Japan

For reprints and all correspondence: Haruki Kume, Department of Urology, Tokyo University Hospital, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: kume{at}kuc.biglobe.ne.jp

Received July 19, 2007; accepted November 21, 2007

We present a case of metastatic testicular immature teratoma that was successfully treated despite resistance to standard chemotherapy and unsuccessful salvage surgery. At first, BEP (bleomycin, etoposide and cisplatin) treatment was performed but failed. The patient underwent incomplete retroperitoneal lymph node dissection. He was then referred to us. By the time of the referral lung and mediastinal lymph node metastasis had appeared and para-aortic lymph node metastasis had grown larger. We administered the DIP (docetaxel, ifosfamide and cisplatin) regimen as a second line chemotherapy, which was effective with 82% reduction of para-aortic lymph nodes, 88% of mediastinal lymph nodes and 85% of lung metastasis. We performed para-aortic lymph node dissection followed by resection of lung metastasis and mediastinal lymph node dissection. The patient is now followed-up at the outpatient clinic without evidence of recurrent disease 3.5 years after the last surgery.

Key Words: testicular cancer • immature teratoma • chemotherapy • DIP


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