Japanese Journal of Clinical Oncology Advance Access originally published online on June 23, 2008
Japanese Journal of Clinical Oncology 2008 38(7):469-473; doi:10.1093/jjco/hyn053
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© The Author (2008). Published by Oxford University Press. All rights reserved
Four-year Experience of Interstitial Permanent Brachytherapy for Japanese Men with Localized Prostate Cancer
1 Department of Radiology
2 Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
3 Division of Radiation Oncology, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
For reprints and all correspondence: Hiromichi Ishiyama, Department of Radiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Japan. E-mail: hishiyam{at}kitasato-u.ac.jp
Received April 17, 2008; accepted May 28, 2008
Objective: To report 4 year results obtained with our initial 100 patients with localized prostate cancer treated by interstitial permanent brachytherapy.
Methods: One-hundred Japanese men with clinically localized prostate cancer underwent interstitial permanent prostate brachytherapy using 125I seeds. Median follow-up was 36 months (range, 30–42 months). Median initial prostate-specific antigen (PSA) level was 6.7 ng/ml (range, 1.5–25.2 ng/ml). Of these 100 patients, 31 received neoadjuvant hormone therapy for several months. Treatment morbidities were assessed using Radiation Therapy Oncology Group (RTOG) scale and National Cancer Institute Common Toxicity Criteria.
Results: A mean of 95 seeds (range, 48–123 seeds) were successfully implanted in patients with prostate cancer. Mean prostate volume receiving at least 100% dose (V100) and dose to 90% of prostate volume (D90) for the 100 patients were 96.6% and 166.1 Gy, respectively. Urinary morbidity was common, but was usually not severe. Only four patients needed catheterization for urinary retention (Grade 3) during follow-up. Most patients displayed no rectal morbidity after implantation, with only 3% of patients showing RTOG Grade 2 rectal morbidity and no patients showing morbidity of Grade 3 or more. Three patients experienced biochemical failure according to Phoenix consensus definition during follow-up. One patient displayed clinical failure with lymph node recurrence.
Conclusions: These results indicate that interstitial permanent brachytherapy is safe and effective for Japanese patients with localized prostate cancer. The import of matured techniques developed in Western countries might allow bypass of the trial-and-error process in Japanese institutions.
Key Words: prostate cancer • brachytherapy • 125I • urinary morbidity • rectal morbidity
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Hashine, Y. Kusuhara, N. Miura, A. Shirato, Y. Sumiyoshi, and M. Kataoka Health-related Quality of Life using SF-8 and EPIC Questionnaires after Treatment with Radical Retropubic Prostatectomy and Permanent Prostate Brachytherapy Jpn. J. Clin. Oncol., August 1, 2009; 39(8): 502 - 508. [Abstract] [Full Text] [PDF]
|
|