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Japanese Journal of Clinical Oncology Advance Access originally published online on July 11, 2008
Japanese Journal of Clinical Oncology 2008 38(7):480-485; doi:10.1093/jjco/hyn059
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© The Author (2008). Published by Oxford University Press. All rights reserved

A Prospective Longitudinal Study Comparing a Radical Retropubic Prostatectomy and Permanent Prostate Brachytherapy Regarding the Health-related Quality of Life for Localized Prostate Cancer

Katsuyoshi Hashine1, Yoshito Kusuhara1, Noriyoshi Miura1, Akitomi Shirato1, Yoshiteru Sumiyoshi1 and Masaaki Kataoka2

1 Department of Urology
2 Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan

For reprints and all correspondence: Katsuyoshi Hashine Department of Urology, National Hospital Organization Shikoku Cancer Center, 160 Minamiumemoto, Matsuyama 791-0280, Japan. E-mail: khashine{at}shikoku-cc.go.jp

Received March 27, 2008; accepted June 11, 2008

Objective: The health-related quality of life (HRQOL) after a radical retropubic prostatectomy (RRP) or a permanent prostate brachytherapy (PPB) was prospectively compared at a single institute.

Methods: Between 2003 and 2005, 122 patients were treated by RRP and 82 patients were treated by PPB. A QOL survey was completed at baseline, and 1, 3, 6 and 12 months after treatment, prospectively.

Results: The general HRQOL was not different between the RRP and PPB groups after 3 months. However, at 1 month after treatment, the general HRQOL scores, except for general health, were significantly better in the PPB group than that in the RRP group. Moreover, the disease-specific QOL was worse in urinary and sexual functions in the RRP group. Urinary function in the RRP group had not recovered to baseline after 12 months. Although the urinary function in the PPB group was better than that of the RRP group, urinary bother continued to worsen until 6 months and thereafter it recovered gradually. The bowel function was not worse in the PPB group but bowel bother was worse at 6 months in the PPB group. In the RRP group, the patients with nerve sparing demonstrated better in sexual function than those without nerve sparing, but the recovery did not reach the level of the PPB group.

Conclusions: This prospective study revealed the differences in the QOL after RRP and PPB. These results will be helpful for making treatment decisions.

Key Words: quality of life • localized prostate cancer • radical retropubic prostatectomy • permanent prostate brachytherapy


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 Jpn J Clin OncolHome page
K. Hashine, Y. Kusuhara, N. Miura, A. Shirato, Y. Sumiyoshi, and M. Kataoka
Health-related Quality of Life using SF-8 and EPIC Questionnaires after Treatment with Radical Retropubic Prostatectomy and Permanent Prostate Brachytherapy
Jpn. J. Clin. Oncol., August 1, 2009; 39(8): 502 - 508.
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