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Japanese Journal of Clinical Oncology Advance Access originally published online on June 16, 2009
Japanese Journal of Clinical Oncology 2009 39(9):560-568; doi:10.1093/jjco/hyp065
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© The Author (2009). Published by Oxford University Press. All rights reserved

The Predictive Role of E-cadherin and Androgen Receptor on In Vitro Chemosensitivity in Triple-negative Breast Cancer

Ja Seung Koo1, Woohee Jung1 and Joon Jeong2

1 Department of Pathology, Yonsei University College of Medicine
2 Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea

For reprints and all correspondence: Ja Seung Koo, Department of Pathology, Yonsei University College of Medicine, Severance Hospital, 250 Seongsanno, Seodaemun-gu, Seoul, South Korea. E-mail: kjs1976{at}yuhs.ac

Received March 22, 2009; accepted May 12, 2009

Objective: The purpose of this study was to evaluate the impact of various pathologic and biologic factors in triple-negative breast cancer (TNBC) on chemotherapy response using in vitro ATP-based chemotherapy response assay (ATP-CRA).

Methods: Forty-seven cases of TNBC were included. Immunohistochemical stains for androgen receptor (AR), p53, CD10, c-kit, CK5/6, vimentin, bcl-2, E-cadherin, Ki-67 and epidermal growth factor receptor were performed. In vitro ATP-CRA was used to analyze chemosensitivity for 5-fluorouracil (5-FU), docetaxel, doxorubicin, epirubicin, vinorelbine, gemcitabine, methotrexate (MTX), oxaliplatin and paclitaxel.

Results: The results showed that all cytotoxic agents demonstrated the trend that E-cadherin-expressing cases had a higher cell death rate than E-cadherin-negative cases. Particularly, vinorelbine showed statistical significance (P = 0.004). Cases with AR expression showed higher cell death rates than those without in 5-FU and MTX (P = 0.012 and 0.014, respectively).

Conclusions: E-cadherin and AR could be candidate predictive factors for chemotherapy response in TNBC. Further in vivo study is required to clarify their roles.

Key Words: androgen receptor • breast cancer • chemosensitivity • E-cadherin • triple negative


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