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Japanese Journal of Clinical Oncology Advance Access published online on May 31, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi093
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© 2005 Foundation for Promotion of Cancer Research
Received July 26, 2004
Accepted February 15, 2005

Case Report

A Long-term Survival Case of Small Cell Lung Cancer in an HIV-infected Patient

Tetsuro Kato 1*, Ryuji Ieki 1, Erika Saito 1, Tomohiro Ota 1, Kazumi Yuasa 1, Mari Iguchi 1, Tatsuru Okamura 1, and Masahiko Shibuya 1

1 Division of Respiratory Disease, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

* To whom correspondence should be addressed.
Tetsuro Kato, E-mail: katetsu{at}av5.mopera.ne.jp


  Abstract

We report a case of small cell lung cancer in a patient with human immunodeficiency virus (HIV) infection. The patient was a 51-year-old man diagnosed 8 years previously as seropositive for HIV, who was admitted to our hospital for re-evaluation of antiretroviral medications due to multidrug resistance. Chest radiograph revealed an abnormal hilar shadow subsequently confirmed to be small cell lung cancer. He received chemotherapy concurrently with highly active antiretroviral therapy (HAART), and lived for 14 months after the diagnosis. The prognosis of lung cancer in HIV-seropositive patients is very poor, and adverse effects of chemotherapy occur more frequently than in other patients. However, the simultaneous antiretroviral agents and combination chemotherapy was successful. Such treatment may be effective despite an otherwise poor prognosis, including HIV infection.

Keywords: small cell lung cancer; human immunodeficiency virus (HIV); highly active antiretroviral therapy (HAART).
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