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Japanese Journal of Clinical Oncology Advance Access published online on June 23, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi105
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© 2005 Foundation for Promotion of Cancer Research
Received December 2, 2004
Accepted March 8, 2005

Case Report

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue (MALT Lymphoma) in the Thymus: Report of Four Cases

Kimihiro Shimizu 1, Genichiro Ishii 2, Kanji Nagai 1, Tomoyuki Yokose 2, Kenichi Ishizawa 3, Junichi Tamaru 4, Junji Yoshida 1, Mituyo Nishimura 1, and Atushi Ochiai 2*

1 Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
2 Pathology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
3 Division of Oncology/Hematology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
4 Pathology Division, Saitama General Medical Center Hospital, Kawagoe, Saitama, Japan

* To whom correspondence should be addressed.
Atushi Ochiai, E-mail: aochiai{at}east.ncc.go.jp


  Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma in the thymus is extremely rare, and little is known about its clinicopathological features. In this study, we examined four cases of MALT lymphoma in the thymus at our institute in terms of clinicopathological features. Most patients had autoimmune disease or hyperglobulinemia, and they also had cysts in the tumors. Both elevated serum levels of autoantibodies and the polyclonal increase in serum Ig remained almost unchanged after total thymectomy in all patients. We recommend that MALT lymphoma in the thymus should be considered in the differential diagnosis when a cystic thymic mass is found and if the patient is Asian and/or has autoimmune disease or hyperglobulinemia.

Keywords: MALT lymphoma; thymus; autoimmune disease; hyperglobulinemia.
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