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Japanese Journal of Clinical Oncology Advance Access published online on November 7, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi174
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© 2005 Foundation for Promotion of Cancer Research
Received July 13, 2005
Accepted September 7, 2005

Original Article

Long-Term Outcomes of 60 Gy Conventional Radiotherapy Combined with Androgen Deprivation for Localized or Locally Advanced Prostate Cancer

Katsuyoshi Hashine 1*, Kosaku Numata 1, Koji Azuma 1, Yoshiteru Sumiyoshi 1, and Masaaki Kataoka 2

1 Department of Urology, National Organization Shikoku Cancer Center, Matsuyama, Japan
2 Department of Radiology, National Organization Shikoku Cancer Center, Matsuyama, Japan

* To whom correspondence should be addressed.
Katsuyoshi Hashine, E-mail: khashine{at}shikoku-cc.go.jp


  Abstract

Background: Until 1998 in Japan, very few institutions were treating prostate cancer solely with radiotherapy (RT) >70 Gy and most were using ≤65 Gy in combination with hormone therapy. The present study reports the long-term results of RT combined with hormone therapy for localized and locally advanced prostate cancer.

Methods: We investigated 57 patients who were treated by external beam RT plus hormone therapy (median age 79 years, median prostate-specific antigen concentration 15.0 ng/ml) between 1992 and 1998. Patients received 40 Gy of radiation to the pelvis and an additional 20 Gy as a prostatic boost. Hormone therapy was begun on the first day of irradiation and continued thereafter.

Results: The median follow-up was 93.3 months and the 5 and 10 year actual overall survival rates were 67.8 and 32.6%, respectively, with 5 and 10 year cause-specific survival rates of 97.9 and 95.0%, respectively. The expected survival rate was 66.2% at 5 years, and overall survival was above expected survival. Only one patient developed severe proctitis (Grade 3). The 5 year occurrence of Grade 1/2 genitourinary toxicity was 23.2%.

Conclusions: Combined RT and hormone therapy has a good long-term outcome without severe adverse events. The overall survival rate compares well with the expected survival rate.

Keywords: prostate cancer; radiotherapy; hormone therapy; long-term outcome.
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[Abstract] [Full Text] [PDF]


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