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Japanese Journal of Clinical Oncology Advance Access published online on November 7, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi178
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© 2005 Foundation for Promotion of Cancer Research
Received July 10, 2005
Accepted August 28, 2005

Original Article

Preoperative Chemotherapy and Radiation Therapy for Squamous Cell Carcinoma of the Maxillary Sinus

Koichi Isobe 1*, Takashi Uno 1, Toyoyuki Hanazawa 2, Hiroyuki Kawakami 1, Seiji Yamamoto 1, Homare Suzuki 2, Yumiko Iida 2, Naoyuki Ueno 1, Yoshitaka Okamoto 2, and Hisao Ito 1

1 Department of Radiology, Chiba University Hospital, Chiba, Japan
2 Department of Head and Neck Surgery, Chiba University Hospital, Chiba, Japan

* To whom correspondence should be addressed.
Koichi Isobe, E-mail: isobeko{at}ho.chiba-u.ac.jp


  Abstract

Objective: This study was undertaken to assess the prognostic factors for the management of squamous cell carcinoma (SCC) of the maxillary sinus, who received preoperative chemotherapy and radiation therapy (RT). We also elucidated the appropriate sequence of chemotherapy.

Methods: A total of 124 patients (median age 62 years) with SCC of the maxillary sinus were analysed retrospectively. T3 or T4 disease was found in 93% of the patients. Thirty-nine patients received neoadjuvant chemotherapy (NA), 38 patients received concurrent chemoradiotherapy (CRT) and 47 patients received NA followed by CRT. The median dose of RT was 60 Gy. Maxillectomy was undertaken in 98 patients.

Results: The 5 year overall survival (OAS) and local control probability (LCP) were 56.6 and 73.7%, respectively. On univariate analysis, surgery (P < 0.0001) and T classification (P < 0.04) were significant prognostic factors for OAS and LCP. Histological grade and nodal status were also related to OAS. However, any chemotherapy sequence was not associated with the treatment outcome. On multivariate analysis, surgery (P < 0.0005) and T classification (P < 0.05) were identified as significant prognostic factors for LCP and OAS.

Conclusions: This study suggests that both surgery and T stage are important prognostic factors for LCP and OAS in the management of SCC of the maxillary sinus. The appropriate sequence of chemotherapy remains to be elucidated in the future study.

Keywords: maxillary sinus carcinoma; SCC; chemotherapy; radiation therapy; prognostic factor.
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