Japanese Journal of Clinical Oncology Advance Access published online on November 28, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi196
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1 Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
* To whom correspondence should be addressed. Objective: To investigate the expression of cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in gastric carcinomas, and to correlate this expression with clinicopathological parameters and angiogenesis. Methods: Ninety-six resected tumor specimens from patients with gastric carcinoma were obtained, and 30 corresponding paracancerous normal tissues were randomly selected as a control. Immunohistochemical staining was used for detecting the expression of COX-2 and MMP-9. Monoclonal antibody against CD34 was used for displaying vascular endothelial cells, and microvascular density (MVD) was calculated by counting of CD34-positive vascular endothelial cells. Results: The positive expression rates of COX-2, MMP-9 and MVD in the cancerous tissue were 80.2%, 74.0%, and 32.5 ± 8.3, respectively, which were significantly higher than those in the normal tissue (P < 0.01). COX-2, MMP-9 expression rates and MVD in the patients with stages III and IV were 91.4%, 84.5% and 34.9 ± 8.7, respectively, which were significantly higher than those in the patients with stages I and II (P < 0.01). In addition, the Spearman rank correlation test showed that tumor MVD was closely associated with COX-2 (r = 0.311, P < 0.01) and MMP-9 (r = 0.349, P < 0.01) expressions. Conclusions: Overexpression of COX-2 and MMP-9 is related to tumor invasion and lymph node metastasis in the gastric carcinoma. These results provide evidence that COX-2 contribute to gastric cancer development by promoting MMP-9 expression and angiogenesis.
Received July 17, 2005
Accepted October 9, 2005
Original Article
Expression of Cyclooxygenase-2 and Matrix Metalloproteinase-9 in Gastric Carcinoma and its Correlation with Angiogenesis
Wei Hao Sun 1 *,
Yun Liang Sun 1,
Ren Nian Fang 2,
Yun Shao 1,
Hai Chen Xu 1,
Qi Ping Xue 1,
Guo Xian Ding 1,
and
Yun Lin Cheng 1
2 Department of Pathology, Chaohu City Second People's Hospital, Chaohu, Anhui province, China
Wei Hao Sun, E-mail: weihaosun{at}hotmail.com
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